Ключевые публикации

Полный список публикаций на Pubmed

  1. Efimov, G.F., Kruglov, A.A., Khlopchatnikova, Z., Rozov, F., Mokhonov, V.V., Rose-John, S., Scheller, J., Gordon, S., Stacey, M., Drutskaya, M.S., Tillib, S.V., and Nedospasov, S.A.. Cell type-restricted anti-cytokine therapy: TNF inhibition from one pathogenic source. Proc. Natl. Acad. Sci. USA, 2016 13(11): 3006-11.
  2. Lemos, D.R., Babaeijandaghi, F., Low, M., Chang, C.-K., Lee, S.T., Fiore, D., Zhang, R.-H., Natarajan, A., Nedospasov, S.A., Rossi, F.M.V. Nilotinib reduces muscle fibrosis in chronic muscle injury by promoting TNF-mediated apoptosis of fibro/adipogenic progenitors. Nat Med. 2015, 21(7): 786-794.
  3. Kruglov, A.A., Grivenninkov, S.I., Kuprash, D.V., Winsauer, C., Prepens, S., Seleznik, G.M., Eberl, G., Littman, D., Heikenwalder, M., Tumanov, A.V., and Nedospasov, S.A. Non-redundant function of soluble LTa3 produced by innate lymphoid cells in intestinal homeostasis. Science 2013, 342(6163): 1243-1246.
  4. Kruglov, A.A., Lampropoulou, V., Fillatreau, S. and Nedospasov, S.A. Pathogenic and protective functions of TNF in neuroinflammation are defined by its expression in T lymphocytes and myeloid cells. J. Immunol. 2011, 187: 5660-5670.
  5. Tumanov, A.V., Koroleva, E.P., Guo, X., Wang, Y., Kruglov, A., Nedospasov, S., Fu, Y.X. Lymphotoxin controls the IL-22 protection pathway in gut innate lymphoid cells during mucosal pathogen challenge. Cell Host Microbe. 2011, 10: 44-53.
  6. Tumanov, A.V., Kruglov, A.A., Grivennikov, S.I., Shebzukhov, Y.V., Koroleva, E.P., Piao, Y., Cui, C.-Y., Kuprash, D.V., and Nedospasov, S.A. Cellular source and molecular form of TNF specify its distinct functions in the development and maintenance of secondary lymphoid tissues. Blood 2010, 116: 3456-3464.
  7. Amirante, M., Luo, J.-L., Grivennikov, S.I., Nedospasov, S.A. and Karin, M. B cell-derived lymphotoxin promotes castration-resistant prostate cancer. Nature 2010. 464: 302-305.
  8. Haybaeck, J., Zeller, N., Wolf, M.J., Wagner, U., Kurrer, M.O., Bremer, J., Weber, A., Iezzi, G., Graf, R., Clavien, P.-A., Thimme, R., Blum, H., Nedospasov, S.A., Karin, M., Kopf, M., Aguzzi, A., and Heikenwalder, M. A lymphotoxin-driven pathway to hepatocellular carcinoma. Cancer Cell 2009. 16: 295-308.
  9. Cui, C.-Y., Hashimoto, T., Grivennikov, S.I., Piao, Y., Nedospasov, S.A., and Schlessinger, D. Ectodysplasin activates the lymphotoxin-? pathway for hair follicle differentiation. Proc. Natl. Acad. Sci. USA 2006, 103 :9142-9147.
  10. Liepinsh, D.J., Grivennikov, S.I., Lagarkova, M.A., Drutskaya, M.S., Klarmann, K.D., Lockett, S.J., McAuliffe, M., Tessarollo, L., Keller, J.R., Kuprash, D.V. and Nedospasov, S.A. Novel Lymphotoxin ? knockout mice with unperturbed TNF expression: reassessing LT? biological functions. Mol. Cell. Biol. 2006, 26, 4214-4225.
  11. Grivennikov, S.I., Tumanov, A.V., Liepinsh, D.J., Kruglov, A.A., Marakusha, B.I., Shakhov, A.N., Murakami, T., Drutskaya, L.N., Fцrster, I., Clausen, B.E., Tessarollo, L., Ryffel, B., Kuprash, D.V., and Nedospasov, S.A. Distinct and non-redundant in vivo functions of TNF produced by T cells and macrophages/ neutrophils: protective and deleterious effects. Immunity 2005, 22: 93-104.
  12. Lin, Y., Choski, S., Shen, H.-M., Yang, Q-F., Hur, G.-M., Kim, Y.S., Tran, J.T., Nedospasov, S.A., and Liu, Z.-G. TNF induced non-apoptotic cell death requires RIP mediated cellular reactive oxygen species accumulation. J. Biol. Chem. 2004, 279:10822-10828.
  13. Abe, K., Yarovinsky, F., Murakami, T., Ito, D., Tumanov, A.V., Pfeffer, K., Shakhov, A.N., Drutskaya, L.N., Kuprash, D.V., Komschlies, K.L., and Nedospasov, S.A. Distinct role of TNF/LT subfamily of cytokines in the development and recruitment of dendritic cells. 2003. Blood 101, 1477-1483.
  14. Kuprash D.V. Alimzhanov M.B., Tumanov A.V., Shakhov, A.N., Grivennikov S.I., Marino, M.W., Turetskaya, R.L., Anderson A.O., Rajewsky K., Pfeffer K. and Nedospasov S.A. Redundancy in TNF and LT signaling in vivo: mice with inactivation of the entire TNF/LT locus versus single knockout mice. 2002. Mol. Cell Biol. 22: 8626-8634.
  15. Tumanov, A.V., Kuprash, D.V., Lagarkova, M.A., Abe, K., Shakhov, A.N., Drutskaya. L.N., Stewart C.L., Chervonsky, A.V. and Nedospasov, S.A. Distinct role of surface lymphotoxin expressed by B cells in the organization of secondary lymphoid tissues. 2002. Immunity 17, 239-250.
  16. Ito D., Back T.C., Shakhov A.N., Wiltrout R.H., and Nedospasov S.A. Mice with a targeted mutation in Lymphotoxin-? exhibit enhanced tumor growth and metastasis: impaired NK cell development and recruitment. 1999. J. Immunol. 163, 2809-2915.
  17. Kuprash D.V., Udalova I.A., Turetskaya R.L., Kwiatkowski D., Rice N.R. and Nedospasov S.A. Similarity and differences between human and murine TNF promoters in their response to LPS. 1999. J. Immunol. 162, 4045-4052.
  18. Endres R., Alimzhanov M.B., Plitz T., Fuetterer A., Kosco-Vilbois M.H., Nedospasov S.A., Rajewsky K., and Pfeffer K. Mature follicular dendritic cell networks depend on expression of lymphotoxin beta receptor by radioresistant stromal cells and of lymphotoxin beta and Tumor Necrosis Factor by B cells. 1999. J. Exp. Med. 189, 159-168.
  19. Alimzhanov M.B., Kuprash D.V., Kosco-Vilbois M.H., Luz A., Turetskaya R.L., Tarakhovsky A., Rajewsky K., Nedospasov S.A., and Pfeffer K. Abnormal development of secondary lymphoid tissues in lymphotoxin ?-deficient mice. Proc. Natl. Acad. Sci. USA, 1997, 94, 2117-2122.
  20. Kuprash, D.V., Osipovich, O.A., Pokholok, D.K., Alimzhanov, M.B., Biragyn, A., Turetskaya, R.L. and Nedospasov, S.A. Functional Analysis of the Lymphotoxin-promoter. Sequence requirements for PMA activation. 1996, J. Immunol. 156, 2465-2472.
  21. Stuber, F., Udalova, I.A., Book, M., Drutskaya, L.N., Kuprash, D.V., Turetskaya, R.L., Schade, F.U., and Nedospasov, S.A. The -308 TNF polymorphism is not associated with survival in severe sepsis and is unrelated to LPS-inducibility of the human TNF promoter. J. Inflam.1996, 46, 42-50.
  22. Biragyn, A., and Nedospasov, S.A. Lipopolysaccharide-induced expression of TNF-? gene in the macrophage cell line ANA-1 is regulated at the level of transcription processivity. J. Immunol. 1995, 155, 674-683.
  23. Kuprash, D.V, Udalova, I.A., Turetskaya, R.L., Rice, N.R. and Nedospasov, S.A. Conserved ?B element located downstream of Tumor Necrosis Factor a gene: distinct NF-?B binding pattern and enhancer activity in LPS activated murine macrophages. Oncogene, 1995, 11, 97-106.
  24. Pokholok, D.K., Maroulakou, I.G., Kuprash, D.V., Alimzhanov, M.B., Kozlov, S.V., Novobrantseva, T.I., Turetskaya, R.L., Green, J.E., and Nedospasov S.A. Cloning and in situ transcriptional analysis of the murine lymphotoxin-beta (LT-?) gene. Proc. Natl. Acad. Sci. USA 1995, 92, 674-678.
  25. Nedospasov S.A., Udalova I.A., Kuprash D.V., and Turetskaya R.L. DNA sequence polymorphism at the human TNF locus. Numerous TNF/LT alleles tagged by two closely linked microsatellites in the upstream region of lymphotoxin (TNF-?) gene. J. Immunol. 1991. 147: 1053-1059.
  26. Shakhov A.N., Collart M., Vassalli P., Nedospasov S.A., and Jongeneel C.V. ?B-type enhancers are involved in LPS-mediated transcriptional activation of the tumor necrosis factor a gene in primary macrophages. J. Exp. Med. 1990. 171, 35-48.
  27. Muller U., Jongeneel C.V., Nedospasov S.A., Fisher Lindall K., and Steinmetz M. Tumor necrosis factor and lymphotoxin genes map close to H-2D in the mouse major histocompatibility complex. Nature, 1987. 325, 265-267.
  28. Spies T., Morton C.C., Nedospasov S.A., Fiers W., Pious D., and Strominger J.L. Genes for the tumor necrosis factors ? and ? are linked to the human major histocompatibility complex. Proc. Natl. Acad. Sci. USA 1986. 83, 8699-8702.
  29. Nedospasov S.A., Hirt B., Shakhov A.N., Dobrynin V.N., Kawashima E., and Jongeneel C.V. The genes coding for tumor necrosis factor (TNF-?) and lymphotoxin (TNF-?) are tandemly arranged on the chromosome 17 of the mouse. Nucleic Acids Res. 1986. 14, 7713-7725.